Risk Factors For Asperger’s Syndrome

Several risk factors exist for Asperger's Syndrome

Several risk factors exist for Asperger’s Syndrome

There are several risk factors that contribute to Asperger’s Syndrome. These factors are divided into those that are inherited and those that are caused by environmental influences.


Males have a greater likelihood of developing Asperger’s than females. The ratio is as high as 5:1. However, it is not known why more males than females develop Asperger’s. Some research has shown that certain birth practices may play a small role in this discrepancy between males and females with Asperger’s but the data is inconclusive and further study is needed.


There is strong evidence that Asperger’s is, at least in part, an inherited condition. Identical twins, in which all the genes are shared by the two siblings, are at risk of developing Asperger’s. For example, if one twin develops Asperger’s, there is a 60% likelihood that the other will develop Asperger’s as well. Younger children born into families with an older children with Asperger’s have a 5-6% likelihood of also having Asperger’s.

Even though the incidence of Asperger’s is higher among related family members, no specific gene has been linked to the development of Asperger’s. There is also currently no way to test for the genetic predisposition towards Asperger’s.

Environmental Causes

Some researchers believe that Asperger’s is caused more by exposure to environmental causes than by genetics especially if a person is born with a predisposition toward Asperger’s. Some of the suggested environmental stimuli include:

  • Viral or bacterial infections during pregnancy
  • A mother who smoked while pregnant
  • Parents who are older at the time of pregnancy
  • Air pollution
  • Pesticide exposure

Some evidence exists to support these environmental factors. For example, women who were exposed to the rubella infection while they were pregnant have a 7% risk of giving birth to a child who develops Asperger’s. Women who smoked during pregnancy have a 40% chance of having a child who develops Asperger’s. Less evidence is available to show a connection between age of parents at pregnancy and exposure to air pollution or pesticides.

Neurological Causes

Brain studies have indicated that connections between certain systems in the brain are different in people with Asperger’s. The systems involved are the amygdala, which processes emotions, and the limbic system, which relays those emotional responses to the cerebral cortex, the center for organization and action. There seems to be some differences in the way the amygdala and limbic systems are connected for people with Asperger’s, which may explain why they can suddenly experience extreme emotional reactions even to trivial objects or events.

Research has also focused on mirror neurons, which enable an individual to mirror another person’s actions. A mirror neuron, for example, is what allows a baby to smile in reaction to a mother’s smile. Studies of children with Asperger’s have discovered that mirror neurons in these children do not respond in the ways they do in children without Asperger’s. Difficulties with mirror neurons may explain why some individuals with Asperger’s have problems with learning and social interactions.

Psychological Causes

Research into psychological factors behind Asperger’s focus on a concept called “theory of mind.” This refers to an individual’s ability to understand others’ emotional states, one’s capacity to see the world through the eyes of the other person. The majority of children who do not have Asperger’s develop skills in anticipating how others think and feel by the time they are approximately four years of age.

Children with Asperger’s have no understanding of the “theory of mind” or a very limited capacity to appreciate what others are thinking and/or feeling. This is a major cause of the social problems that people with Asperger’s experience.

In summary, the exact causes of Asperger’s are unknown. The most we can say is that the combination of genetic factors along with environmental, neurological and psychological causes probably determines the severity and symptoms for each individual with Asperger’s Syndrome.

Dr. Kenneth Roberson is an Asperger’s psychologist in San Francisco with over 30 years of experience. To ask a question, or schedule an appointment,
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